Update
Our review is now officially published in the Journal of Biological Chemistry! While the sequence of amino acids is a critical determinant of how a protein folds and behaves, some proteins play by a different ruleset. These proteins have “composition-driven activities”, where the amino acid composition is a stronger determinant of the activity than the linear sequence of amino acids. This review discusses known examples of composition-driven activities, as well as experimental criteria for classifying activities as composition-driven. You can read the paper here.
The Ross Lab is in the department of Biochemistry and Molecular Biology at Colorado State University. Our primary research interests involve prions and prion-like proteins, although we are also actively investigating the functions, structures, and regulation of low-complexity domains within proteins.
Our primary research toolkit includes:
- Yeast genetics
- Fluorescence microscopy
- Protein purification and in vitro biochemistry
- Bioinformatics
Go to the Research Interests tab to read more about what we do.
